by Judith Curry Some interesting articles that I’ve spotted recently.

Covid discussion thread: Part IX — Climate Etc.

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Covid discussion thread: Part IX

Posted on June 14, 2020 by curryja | 1 Comment

by Judith Curry

Some interesting articles that I’ve spotted recently.

This is really a fantastic manuscript on what we know today about #COVID19 biology and immunology. https://cell.com/immunity/pdf/S1074-7613(20)30183-7.pdf

Fine COVID19 seroprevalence study in hard-hit Geneva finds peak at 10·8%. Also, for every confirmed case, there were ~12 undetected. Epidemic is far from coming to an end by means of fewer susceptible people in population. https://thelancet.com/action/showPdf?pii=S0140-6736%2820%2931304-0…

German study which concludes that making masks compulsory reduces daily growth rate in infections by 40%.[link]

“The speed by which structural information on the #SARSCoV2 virus has been collected is astonishing.” And that’s paving many ways to block it; a brief and helpful overview https://nature.com/articles/s41467-020-16779-4

There are now 2 series of people who were asymptomatic but had lung CT scans Diamond Princess https://pubs.rsna.org/doi/10.1148/ryct.2020200110… Korea https://medrxiv.org/content/10.1101/2020.05.09.20096370v1… Both showed a high % of abnormalities, ground-glass opacities

‘Superforecasters’ Are Making Accurate Predictions About COVID-19 [link]

#COVID19 vaccine development is moving forward at an unprecedented speed on the global efforts and challenges .https://sandiegouniontribune.com/news/science/story/2020-06-06/race-for-vaccine

“Norwegian scientist Birger Sørensen has claimed #SARSCoV2 is not natural in origin. The study from Sørensen and British professor Angus Dalgleish show that #coronavirus’ spike protein contains sequences that appear to be artificially inserted.“ [link]Study suggests Vitamin K could help fight coronavirus [link]

pparently SARS-CoV-2 has another method of entering cells besides the ACE-2 receptor, a surface protein called NRP1. This would have an impact on the efficacy of HCQ with respect to blocking the virus’ entry into a cell. HCQ blocks ACE-2 but not NRP1. [link]

This analysis of #covid19 clusters in Japan in the first two and a half months of the epidemic there presents some really interesting data.  https://wwwnc.cdc.gov/eid/article/26/9/20-2272_article

Why COVID-19 makes people lose their sense of smell [link]

“In this cohort, the majority of asymptomatically infected persons remained asymptomatic throughout the course of the infection” https://nejm.org/doi/full/10.1056/NEJMc2013020?query=featured_coronavirus…

Influential model judged reproducible — although software engineers called its code ‘horrible’ and ‘a buggy mess’. [link]

We detect >1300 independently-introduced transmission lineages. [link]

Resistance of children to COVID-19 infection.  How? [link]

HXQ

Does zinc supplementation enhance the clinical efficacy of HXQ in the battle against COVID-19? [link]

Senegal confirms its selection of hydroxychloroquine as a treatment with preliminary study showing hospitalisation’s length of stay of 13 days without HCQ, 11 HCQ alone and 9 HCQ+Azithromycin. https://francetvinfo.fr/monde/afrique/societe-africaine/covid-19-le-senegal-confirme-l-option-de-l-hydroxychloroquine-sur-la-base-d-etudes-preliminaires_3947713.html…

France’s first coronavirus case was in December [link]

Younger adults were the main source of 61 different outbreak clusters in Japan. https://wwwnc.cdc.gov/eid/article/26/9/20-2272_article

Spain: “we implemented a … treatment outside the hospital with hydroxychloroquine plus azithromycin … associated with a reduction in the burden of hospital … successful in terms of the number of patients who have developed serious complications.” [link]

Indonesia will publish a clinical study showing efficacy of combinations of various antibiotics with hydroxychloroquine or Kalestra. They have done exceptionally well against COVID-19 so far. https://jakartaglobe.id/news/indonesia-claims-five-drug-combinations-effectively-reduce-novel-coronavirusTurkey, which uses hydroxychloroquine early for treatment of Covid-19, reports that ICU cases have dropped from 200 in April to 50 today.[link].

India’s health ministry guidelines for Covid-19 treatment now say hydroxychloroquine should be used as early in the disease course as possible and should be avoided in patients with severe cases. https://newsroompost-com.cdn.ampproject.org/c/s/newsroompost.com/india/health-ministry-issues-fresh-clinical-management-protocol-for-covid-19-patients/525911.html/ampUAE will not use hydroxychloroquine on severe cases any more, but still on mild and moderate patients. A few data points on a new promising stem cell treatment that reduced recovery time from 22 days to 6 days for serious cases. [link].

Policy

China defends its coronavirus response in new report https://abcn.ws/2XEzyRs

New evidence of China’s coronavirus cover-up: Scientists KNEW it was lethal and ‘clearly contagious’ before officials told the world about ‘mystery’ outbreak https://mol.im/a/8395163

UK SAGE Report  Britain’s recovery from COVID-19. says test, track & trace system is ‘not fit for purpose’https://independentsage.org/wp-content/uploads/2020/06/IndependentSAGE-report-4.pdf

Dubious modeling is complicating Britain’s lockdown debate [link]

Understanding COVID-19 risks and vulnerabilities among black communities in America: the lethal force of syndemics – http://ow.ly/Xa9C30qOvCb

How to reset the US pandemic response [link]

Sociology 

The American Press is destroying itself [link]

Who’s to blame? These three scientists are at the heart of the Surgisphere COVID-19 scandal [link]

We often accuse the right of distorting science. But the left changed the coronavirus narrative overnight [link]

A delicate balance: weighing protest against the rise of COVID-19 [link]

A researcher involved in the retracted Lancet study has been terminated from the University of Utah faculty. [link]

From lockdown to meltdown: the logic of intolerance [link]

Why the coronavirus is winning [link]

Has the British scientific establishment made its biggest error in history? [link]

Tribalism comes for pandemic science [link]

Abrupt, radical reversal in how public healt experts now speak about coronavirus and mass gatherings [link]

“How a retracted research paper contaminated global #coronavirus research” https://latimes.com/business/story/2020-06-08/coronavirus-retracted-paper…

The news media is destroying itself [link]

Covid-19 studies based on flawed Surgisphere data force medical journals to review processes [link]

Masks can disrupt our ability to communicate and connect. But there are ways to overcome a mask’s necessary downsides. http://ow.ly/WSrm50zSDxk